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49ers star Christian McCaffrey questionable for season opener after calf injury

SANTA CLARA, Calif. (AP) — San Francisco 49ers star running back Christian McCaffrey is questionable for the season opener after hurting his calf at practice this week.

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49ers star Christian McCaffrey questionable for season opener after calf injury

San Francisco 49ers running back Christian McCaffrey walks on the sideline during a preseason NFL football game against the Denver Broncos Saturday, Aug. 9, 2025, in Santa Clara, Calif. (AP Photo/Godofredo A. Vásquez)


SANTA CLARA, Calif. (AP) — San Francisco 49ers star running back Christian McCaffrey is questionable for the season opener after hurting his calf at practice this week.

Coach Kyle Shanahan said on Thursday and wasn’t able to practice with the team at all on Friday. He was doing some work on the side during the open portion of practice.

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